Genomics integrated with breast cancer model systems.
Our laboratory studies toxicological effects in everyday life that act as triggers in the formation of cancer.
Estrogen and antiestrogen regulation of cell cycle in human breast cancer cells.
The role of transcription factors AP-1 and Ets in metastasis.
Protein kinase signaling and targeted therapies in breast cancer and glioblastoma.
Steroid hormones, growth factors, environmental factors and breast cancer risk.
Inflammation, cancer and drug development
Nodal and TGFb family inhibitors in breast cancer.
Immune cells in mammary inflammation and tumorigenesis. C/EBPb regulation of the progesterone receptor.
Understand transcriptional mechanisms in normal cell growth and apoptosis, and dysregulation leading to cancer.
Role of non-coding RNAs in cancer and the environmental toxicants’ effect on development.